Blastocyst Transfer Fertilization process is a technique to grow embryos beyond the 3rd day of culture. When the embryos are cultured for 5 days, they become blastocyst which contains 120 cells & it is ready to implant directly in the uterus
Why is Blastocyst culture not done routinely for all patients?
In 20-30% of patients, none of the embryos develop into blastocyst culture procedure. In these patients, there would be no viable embryo, available for embryo donation process.
No one does not know whether there would be long term adverse effects in exposing embryos for 5 days to the environment but there has been no increase in abnormalities in blastocyst Treatment babies as compared to embryo transfer babies.
Who would qualify for Blastocyst Culture?
Patients who have failed to get pregnant after In Vitro Fertilization treatment/ICSI treatment procedure.
What percentage of embryos will grow to the Blastocyst stage in culture?
For younger patients, up to 70% of all embryos will continue to grow to the blastocyst stage & 10% of patients will not have blastocyst development. As patients get older, only few number of embryos will develop in to blastocyst culture procedure.
What are the risks of blastocyst culturing?
There are two main concerns with blastocyst culture procedure:
Some patients may have no embryo development to blastocyst and thus lose the opportunity for a transfer.
The Survival of embryos after thawing will be less
Are there any limitations to blastocyst culturing?
Yes, if you have less than 4 of, 8-celled quality embryos on 3rd day of culture, we do not proceed for blastocyst culture process. With blastocyst culture process, we are not able to freeze more embryos because of poor development to the blastocyst stage. Also, there is identical twinning & conjoint twinning risk more with blastocyst culture process.
Because of high blastocyst transfer success rates of Motherhood fertility centre, it is considered as one of the leading blastocyst Treatment centre in Hyderabad.
In the blastocyst culture process, one or more embryos are transferred, which are at a very advanced developmental stage, called a blastocyst stage. This blastocyst treatment is usually done on the fifth day after follicular aspiration.
After removal of the eggs from an ovary (follicular aspiration) by the infertility specialists, the eggs are fertilized in the lab of Motherhood fertility centre. This process is done by normal in vitro fertilization treatment (IVF) or by process of intracytoplasmic sperm injection (ICSI).
After the fertilization process, immediately an egg begins to divide and start to develop into an embryo. The developmental stages include:
The pronuclear stage on the first day of the fertilized egg.
The incremental stage of two to four-cell on the second day
They become the eight-cell stage on the third day
They become on morula stage on the fourth day and
Finally, the blastocyst stage on the fifth day.
The best infertility specialists of Hyderabad, working in the Motherhood fertility centre usually inserts one or number of embryos in the uterus of the woman after two to three days of egg retrieval. This process is called embryo transfer.
The transferred embryos can be developed in an incubator up to fifth day i.e. the blastocyst stage, the credit goes to the improved cell culture media called a blastocyst culture procedure. If the specialist transfers such improved embryos into the uterus of the woman, this is considered as blastocyst culture transfer.
Advantages of blastocyst transfer?
It ensures the quality of the embryos: Only fit and good quality embryos can reach the developmental stage of the blastocyst. This permits us single embryo transfer if needed.
It is the normal physiological stage when the embryos are entering into the uterus. Many fertility centres in Hyderabad propose that good or bad embryos can be selected within 3 days of development. But our main struggle is that the uterine lining is not compatible on that 3rd day because the embryo tumbles into the uterus only on the 5th day. Therefore, we carry out day 5 transfers specially in those individuals, who have had multiple implantation failures.
It permits to test or screen those embryos genetically. Biopsy of embryos is done in between 1st to the 2nd day of development and the embryo is allowed to develop. If they are normal, embryos are put back at the blastocyst stage.
It ensures quality control of the blastocyst in the laboratory of Motherhood fertility centre, one of the best Fertility Treatment Centers in Hyderabad.