IUI or Artificial insemination is a technique where fertility is facilitated by inserting several sperms directly into the female gential tract.

It takes 2-3 visits to thoroughly assess both male and female partners.

Female Partner Evaluation: Ideally she should come on D2/D3 of menstrual cycle for hormonal evaluation. Follicular study on day8 of menses for follicle growth, Uterine cavity assessment to rule out endometrial polyps, submucous fibroid intrauterine adhesion etc and also day21 endomertial biopsy, HSG, Diagnostic laparoscopy Hysteroscopy where required.

Male partner Evaluation:Semen analysis after 3D of abstinence, Hormonal evaluation, scrotal Doppler for varicocele.

After thorough examination couple will be counselled regarding their treatment options and also the possible success rate

Candidates selection for IUI

MEN: Men who are unable to ejaculate in the vagina. Causes for ejaculation failure include:

  • Diabetes
  • Multiple sclerosis
  • Spinal cord injury
  • Retrograde ejaculation
  • Men with mildly low sperm count
  • Poor quality sperm or antipserm antibodies. Semen freezed for the future use before vasectomy, chemotherapy or radiotherapy for cancer.


  • Women with mild endometriosis
  • Women with cervical mucus hostility or poor cervical mucus.

Procedure of IUI:

  • First stimulation of ovulation and monitoring.
  • The IUI can be done in a natural cycle or stimulated cycle.

Natural Cycle: The growth of a single egg in the growing follicle is monitored through vaginal sonography. Once the single follicle has reached an average diameter of 1.8 to 2 cm, an HCG injection is given to bring about ovulation (release of egg from the follicle) and IUI is done after 36 to 40 hours.

Stimulated Cycle: Multiple egg formation is achieved through drugs such as Cloimphene Citrate, Gonadotropins (FSH or HMG) alone or in combination with GnRh analogues. A key requirement for most ART treatment is the stimulation of multiple follicles for the production of more than one mature egg, as this is generally associated with improved chances of conception. The growth of the egg is monitored through vaginal sonography that shows follicle size and number.

Timing of IUI: The patient is called for, 36-40 hours after HCG injection (at the time of ovulation). The incidence of ovulation is confirmed through a sonography prior to the insemination. or some times two inseminations are performed-one at 24 hours after HCG and the other at 48 hours after HCG.

Semen Production: The husband is given a sterile container. He is asked to collect sample by masturbation in a semen collection room. Alternatively, he can collect the sample at home and bring to the clinic within a period of 30-45 minutes.

Semen Preparation: The semen is processed in the laboratory, using specially imported culture Media. The semen can be processed and washed either by the standard swim-up method or the density gradient method. The IUI is a short procedure, lasting about 2 hours.

What are the success rates of IUI: The success rates vary from 25-35 % per cycle depending on the cause of infertility. The best results are seen among patients with cervical factor and semen count not less than 20 million per ml.

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